An anaphase calcium signal controls chromosome disjunction in early sea urchin embryos

Article Abstract:

Research was conducted to investigate whether anaphase calcium signals cause chromosome disjunction during first mitosis in sea urchin embryos. An Eppendorf micromanipulator was utilized to harvest boroscilicate glass micropipettes while sea urchin eggs were developed in artificial sea water. Results indicated that calcium regulated chromosome disjunction in the embryos. They also showed delays in spindle elongation resulting from small spindle size.

Mitosis, Chromosomes, Anaphase, Sea urchin embryo

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IP47: a cargo selection device for mannose 6-phosphate receptor trafficking

Article Abstract:

The TIP47 is a 47kDa protein that plays an important role in endosome-to-TGN transport. It binds selectively to the cytoplasmic domains of either cation-dependent or cation-independent mannose 6-phosphate receptors (MPRs). It is also needed in the in vitro and in vivo transportation of MPRs from endosomes to the trans-Golgi network using the phenylalanine/tryptophan signal of the MPR cytoplasmic domain.

Carrier proteins, Transport proteins, Protein binding

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