Antibacterial action of dipeptides containing an inhibitor of glucosamine-6-phosphate isomerase

Article Abstract:

The N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP) conjugated to an amino acid forms a dipeptide with significant antimicrobial properties. The dipeptide is avidly taken up by bacteria and metabolized to its components. FMDP inactivates glucosamine-6-phosphate isomerase, an enzyme necessary for the biosynthesis of a component of bacterial peptidoglycan. Inhibition of this enzyme results in bacteriolysis. FMDP is effective against both bacteria and fungi.

Antibiotics, Enzyme inhibitors

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Efficient secretion of the model antigen M6-gp41E in Lactobacillus plantarum NCIMB 8826

Article Abstract:

Food industry research has established that the Lactobacillus strain Lb. plantarum NCIMB 8826 produces and secretes more heterologous proteins than strains Lb. paracasei LbTGS1.4, Lb. casei ATCC 393 and Lb. fermentum KLD. Lb. plantarum NCIMB 8826 was also capable of secreting a model antigen consisting of the N-terminal part of the M6 protein from bacterium Streptococcus pyogenes fused to the linear epitope ELDKWAS from human immunodeficiency virus gp41 protein.

Food industry, Lactobacillus plantarum

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