Antisense-Mediated depletion reveals essential and specific functions of MicroRNAs in Drosophila development

Article Abstract:

The injection of 2'O-methyl antisense oligoribonucleotides into early 'Drosophila' embryos that leads to specific and efficient depletion of microRNAs and permits systematic loss-of-function analysis in vivo is demonstrated. MicroRNAs act as specific and essential regulators in a wide range of developmental processes.

Biological Product (except Diagnostic) Manufacturing, Nucleic Acid Derivatives, Drosophila, Nucleotides, Antisense DNA

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The developmental miRNA profiles of zebrafish as determined by small RNA cloning

Article Abstract:

The MicroRNA (miRNA) profile of the zebrafish Danio rerio resolved in a developmental and cell type-specific manner is described. A rough estimate of the breadth of gene regulation by miRNAs within one species and the extent of cross-species conversation of specific miRNA-target relationship is revealed.

Zebra fish, Zebra fishes

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A novel class of small RNAs in mouse spermatogenic cells

Article Abstract:

The identification of a novel class of small RNAs in the mouse male germline termed piwi-interacting RNAs (piRNAs) is reported. A subpopulation of piRNAs is associated with polysomes, suggesting their potential role in translational regulation.

Genetic translation, Translation (Genetics)

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