Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin

Article Abstract:

Ikaros proteins are necessary for the development of lymphocytes and natural killer cells. Immunofluorescence in-situ hybridization and confocal microscopy were employed to determine the cellular localization of ikaros proteins. Results reveal that these proteins are localized at centromeric heterochromatin associated with transcriptionally inactive genes. These results indicate that repressed genes are selectively positioned along centromeric domains.

Research, Observations, DNA binding proteins, Centrosomes, Centrosome

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Plant nuclear RNA polymerase IV mediates siRNA and DNA methylation-dependent heterochromatin formation

Article Abstract:

There are three nuclear DNA-dependent RNA polymerases in eukaryotes, which transcribe genomic DNA into RNA, and plants have catalytic subunits for a fourth nuclear polymerase. The RNA Polymerase IV helps produce siRNAs that target de novo cystosine methylation events required for facultative heterochromatin formation and higher-order heterochromatin associations.\

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Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways

Article Abstract:

Dicer-1 and Dicer-2 facilitate the assembly of siRISC (RNA-induced silencing complex). But genetic analysis has demonstrated that Dcr-1 but not Dcr-2 is required for gene silencing by miRNAs.

Analysis, Messenger RNA, Genetic research, Gene silencing

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