Regulation through the secondary channel-structural framework for ppGpp-DksA synergism during transcription

Article Abstract:

A study is conducted to show that the DksA protein is a crucial component of ppGpp-dependent regulation. Biochemical analysis demonstrates that DksA affects transcript elongation, albeit differently from GreA, augments ppGpp effects on initiation and binds directly to RNAP, positioning the Asp residues near the active site.

DNA synthesis

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REG(gamma): A shortcut to destruction

Article Abstract:

Destruction of intact cellular proteins are largely orchestrated by ATP-dependent ubiquitination and subsequent degradation by the 26S proteasome. The proteasomal activator REG(gamma) directs degradation of the steroid receptor coactivator SRC-3 by the 20S proteasome in an ATP- and ubiquitin-independent manner.

United States, Protein research, Steroids (Organic compounds), Steroids

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