Catch the micro1B train to the basolateral surface

Article Abstract:

The ways in which modulating polarized trafficking pathways can give the flexibility to bring on specialized cell types and make the cell able to adapt to changing developmental requirements are discussed in this review article. Protein delivery to distinct apical and basolateral plasma membrane domains of polarized epithelial cells is attractive as a way to look into how specificity of transport is accomplished. The basolateral sorting seems to use a clathrin-based mechanism somewhat like those used for incorporating membrane proteins into clathrin-coated pits at the plasma membrane.

Physiological aspects, Epithelial cells, Cell membranes, Golgi apparatus, Plasma membranes, Polarity (Biology), Clathrin

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"Kissin' cousins": intimate plasma membrane - ER interactions underlie capacitative calcium entry

Article Abstract:

Endoplasmic reticulum (ER) interactions which underlie capacitative calcium entry, a mysterious phenomenon, are discussed in this review article. Topics include the role of the inositol 1,4,5-trisphosphate (IP(sub.3)) receptor in regulating capacitative calcium entry channels and a secretion model for activation of store-operated channels. Vesicles or ER and plasma membrane (PM) may interact in a rapid, nonfusing manner, kind of like the kiss-and-run secretion mode. PM channels may be regulated by diffusible messengers in other cellular systems or in other signaling pathways.

Endoplasmic reticulum, Calcium channels, Proteins, Ligands (Biochemistry), Cell receptors

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A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans

Article Abstract:

Eukaryotic zinc-binding proteins of a novel class are necessary for barley disease-resistance signaling and Caenorhabditis elegans development. Susceptible rsr1 mutants are impaired in the biphasic hydrogen peroxide accumulation and localized cell death in powdery mildew attack. A signaling function for Rar1 is suggested early in the resistance pathway.

United Kingdom, Health aspects, Genetic aspects, Powdery mildew diseases, Caenorhabditis elegans, Barley

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