Characterization of a second cell-associated Arg-specific cysteine proteinase of Porphyromonas gingivalis and identification of an adhesin-binding motif involved in association of the prtR and prtK proteinases and adhesins into large complexes

Article Abstract:

A study was conducted to characterize the second Arg-specific proteinase of Porphyromonas gingivalis and the cloning and sequence analysis of its gene, prtRII. P. gingivalis W50 was prepared in batch culture and harvested at late-exponential phase by centrifugation. Polymerase chain reaction was utilized to amplify a 991 bp fragment supporting the internal Eco721 site encoded by prtRII. Results indicated that prtR resulted from the gene duplication and recombination of ancestral prtRII and adhesin genes.

Research, Diseases, Proteins, Periodontal disease, Periodontal diseases, Etiology (Medicine), Cysteine

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Secretion, interaction and assembly of two O-glycosylated cell wall antigens from Candida albicans

Article Abstract:

A monoclonal antibody (3A10) was raised against the material released from the Candida albicans mycelial cell wall by zymolyase digestion. It appears that after secretion, parts of the O-glycosylated antigen molecules are transferred to an N-glycosylated protein or proteins. The process that results in the final molecular product of each antigen and distribution in the cell walls is discussed.

Fungi, Biosynthesis, Monoclonal antibodies

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Different adhesins for type IV collagen on Candida albicans: identification of a lectin-like adhesin recognizing the 7S(IV) domain

Article Abstract:

Interaction of Candida albicans yeast cells with the three main domains of type IV collagen, a major basement membrane glycoprotein, have been analyzed. The pathogen adhered to the three immobilized domains by different mechanisms. A lectin-like adhesin that recognizes the 7S(IV) domain has been identified.

Mexico, Causes of, Candidiasis, Opportunistic infections, Adhesion

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