Chromatin structure and RNA polymerase II connection: implications for transcription

Article Abstract:

The model that defines the link between RNA polymerase II (pol II) and chromatin indicates the presence of the Swi/Snf complex, a DNA-stimulated ATPase that disrupts the nucleosomal arrays which facilitates the binding of activator proteins to their target sites on nucleosomal templates, in the pol II holoenzyme. In the triad model of transcriptional activation, pol II is recruited to the promoter in active form, where it initiates transcription by forming a metastable triad with the activator and the transcription protein TFIID.

Genetic aspects, Chromatin, Proteins, Genetic regulation, RNA polymerases

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TUF love for "junk" DNA

Article Abstract:

A number of transcripts of unknown function (TUFs) have highlighted the complex transcriptional architecture that includes alternative splice isoforms for almost all protein-coding genes, widespread transcription of antisense RNAs, and abundant noncoding RNAs (ncRNAs) with important biological functions. The landscape of most transcriptomes is a lattice-like network of overlapping transcription in which the same genomic sequences serves as portions of separately regulated transcripts.

Science & research, Research, RNA splicing

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Unbiased mapping of transcription factor binding site along human chromosomes 21 and 22 points to widespread regulation of noncoding RNA's

Article Abstract:

The unbiased mapping of transcription factor binding sites (TFBS) along with human chromosomes 21 and 22 points to widespread regulation to noncoding RNA's is presented. It is inferred that the human genome contains a number of protein-coding and non-coding genes, bound by common transcription factors and regulated by common environmental signals.

Analysis, Composition, Cellular control mechanisms, Cell regulation, Binding sites (Biochemistry), Active sites (Biochemistry), Human genome

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