Reintroduction of the PLB1 gene into Candida albicans restores virulence in vivo

Article Abstract:

Research reveals that phospholipase B1secreted by Candida albicans enables the bacterium to travel through gastrointestinal tract and spread haematogenously, supporting the enzyme's role in the infection process.

Infection, Physiological aspects, Genetic aspects, Virulence (Microbiology), Phospholipases

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Modification of surface properties of biomaterials influences the ability of Candida albicans to form biofilms

Article Abstract:

The effect of surface modifications of polyetherurethane, polycarbonateurethane, and poly(ethyleneterephthalate) (PET) on the formation of the fungal biofilm is investigated. The analysis shows that surface modification is a viable approach for identifying surfaces that have antibiofilm characteristics.

Science & research, Microbial mats, Biomedical materials, Biomaterials

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Cloning and characterization of a gene (LIP1) which encodes a lipase from the pathogenic yeast Candida albicans

Article Abstract:

Cloning of a candidal gene encoding a lipase may help in determining its role in the virulence of the pathogenic fungus, Candida albicans. A complementation strategy was utilized to clone candidal lipases employing Saccharomyces cerevisiae which was transformed with Candida albicans genomic library. The lipolytic activity of the transformed organisms was screened using egg-yolk agar assay. Southern and Northern blot analysis were done to detect the presence of homologous sequences in other species and to monitor the expression of the lipase (LIP1) gene.

Analysis, Lipase

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