The multiple roles of PTEN in tumor suppression

Article Abstract:

Phosphatase and tensin homolog deleted from chromosome 10 (PTEN) has multiple roles in tumor suppression discussed in this review article about this tumor-suppressor gene. The gene is also known as 'mutated in multiple advanced cancers' (MMAC1) or 'TGF(beta)-regulated and epithelial cell-enriched phosphatase' (TEP1). PTEN function may be lost late in tumorigenesis. Topics include apoptosis and cell cycle control, an elusive phosphatase, and adhesion-dependent signaling.

Carcinogenesis, Phosphatases

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Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2

Article Abstract:

Mice that lack the mitotic checkpoint protein Mad2 and their chromosome missegregation and apoptosis are discussed. Mad2 was knocked out in an effort to find the function of the mitotic checkpoint protein Mad2 in normal cell division and when mitosis is not normal. The spindle assembly checkpoint is necessary for correct chromosome segregation in mitotic mouse cells and for embryos to be viable, even where there is no spindle damage.

Mice, mutant strains, Mutant mice, Chromosome replication, Mitosis, Cytogenetics, Spindle (Cell division), Spindle (Cytoplasm)

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Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

Article Abstract:

Crystal structure of the PTEN tumor suppressor is discussed relative to its phosphoinositide phosphatase activity and membrane association. The PTEN C2 domain binds phospholipd membranes in vitro. Mutation of basic residues that could mediate the bindings reduces PTEN membrane affinity and ability to suppress growth of glioblastoma tumor cells. It appears the C2 domain may act to productively position the catalytic domain on the membrane.

Statistical Data Included, Genetic aspects, Cancer, Cancer genetics, Cell membranes, Genetic disorders, Second messengers (Biochemistry), Second messengers (Cytochemistry)

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