Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function

Article Abstract:

Gene targeting was used in mice to look at the function of Scp2, encoding sterol carrier protein-2 (SCP2; a peroxisomal lipid carrier) and sterol carrier protein-x (SCPx; a fusion protein between SCP2 and a peroxisomal thiolase). Peroxisome proliferation, hypolipidemia, poor body weight control, neuropathy and marked changes in gene expression occurred with no SCP2 and SCPx. Catabolism of methyl-branched fatty acyl CoAs was cut back. Accumulation of tetramethyl-branched phytanic acid, a fatty acid, in spc2(-/-) mice occurred. Gene disruption brought on poor import of phytanoyl-CoA into peroxisomes and to unsatisfactory thiolytic cleavage of 3-ketopristanoyl-CoA.

Research, Oxidation, Physiological, Physiological oxidation, Arteriosclerosis, Steroid hormones, Peroxisomes, Cholesterol metabolism

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Role of SVP in the control of flowering time by ambient temperature in Arabidopsis

Article Abstract:

A study was conducted to demonstrate that Short Vegetative Phase (SVP) gene in Arabidopsis plays an important role in the response of plants to ambient temperature changes. SVP controls flowering time by negatively regulating the expression of a floral integrator, Flowering Locus T (FT) via direct binding to the CArG motifs in the FT sequence which is suggested to be one of the molecular mechanisms that modulate flowering time under fluctuating temperature conditions.

Plants, Flowering of, Plant flowering, Arabidopsis, Temperature

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The PAS/ LOV protein VIVID controls temperature compensation of circadian clock phase and development in Neurospora crassa

Article Abstract:

A study to show that, the Neurospora protein VVID (VVD) buffers the circadian system against temperature fluctuations is presented. Result show that temperature compensation of clock-controlled output is a key factor in maintaining temperature compensation of the entire circadian system.

Physiological aspects, Circadian rhythms, Neurospora

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