Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling

Article Abstract:

A study was conducted to show that pluripotent hematolymphoid progenitors undergo T-lineage specification and B-lineage inhibition in response to Notch signaling in a delayed and asynchronous way. It was demonstrated that hematopoietic progenitor cells showed a high level of plasticity in their response to instructive signals provided by Notch and Delta interactions in the context of IL-7, Flt3-L, and OP9 stromal cells.

Lymphocytes, Hematopoietic growth factors

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Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells

Article Abstract:

Three-dimensional fluorescence in situ hybridization is used for studying the simultaneous visualization of looping involving three subregions of the immunoglobulin heavy-chain (IgH) locus. The studies suggest that the repositioning of the Ig loci could have taken place due to a looping mechanism prior to the IgH V(D)J rearrangement and could have facilitated the joining of Ig variable, diversity, and joining segments.

Immunoglobulins

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CTCF mediates long-range chromatin looping and local histone modification in the Beta-globin locus

Article Abstract:

CTCf (CCCTC-binding factor) binds sites around the mouse Beta-globin locus that spatially cluster in the erythroid cell nucleus. A demonstration that both conditional deletion of CTCF and targeted disruption of a DNA-binding site destabilize these long-range interactions and cause local loss of histone acetylation and gain of histone methylation, apparently without affecting transcription at the locus is presented.

Cell nucleus, Methylation, Beta globulins

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