The coregulator exchange in transcriptional functions of nuclear receptors

Article Abstract:

The coregulator exchange in transcriptional functions of nuclear receptors (NRs), which include receptors for steroid hormones, is discussed in this review article. NRs regulate gene expression ligand-dependently, and the superfamily includes numerous orphan receptors, those for which regulatory ligands are not identified. Molecular strategies that are behind NR-regulated gene transcription seem to involve combinatorial actions of a large number of coregulators in a continuum from active repression to strong gene activation. Effects of other adjacent DNA-bound transcription factors, the DNA binding site and coregulators seem to jointly generate recruitment events that regulate the level of repression gene activation. Topics include Swi/Snf/BRG complexes: ATP-dependent chromatin remodeling complexes; complexes with histone/protein acetyltransferase activity; and TRAP/DRIP/ARC.

Physiological aspects, Chromatin, Carrier proteins, Transport proteins, Cellular signal transduction, Cytochemistry, Ligand binding (Biochemistry), Binding sites (Biochemistry), Active sites (Biochemistry), Cell nuclei, Cell nucleus, Adenosine triphosphate, ATP

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Determinants of coactivator LXXLL motif specificty in nuclear receptor transcriptional activation

Article Abstract:

LXXLL-containing motifs may have evolved to permit both receptor-specific and ligand-specific assembly of a coactivator complex. Ligand-dependent activation of gene transcription requires co-activators. The thyroid hormone cannot be activated without the combined participation of two helical domains, and research suggests the core LXXLL motif makes differential contacts with helices 1 and 3 in receptor ligand-binding remains.

Cell research, Cytological research, Genetic research

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Molecular determinants of nuclear receptor-compressor interaction

Article Abstract:

Results demonstrate the molecular basis for the exchange of coactivators for corepressors during development and homeostasis in murine cells is the discrimination by the nuclear receptor AF2 motif of the coactivator and corepressor interacting helices.

Statistical Data Included, Genetic aspects, Developmental genetics, Homeostasis

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