Distinct adhesive behaviors of neurons and neural precursor cells during regional differentiation in the mammalian forebrain

Article Abstract:

A study was conducted to determine whether cells from the three regions of the mammalian forebrian exhibit distinct cell adhesion and recognition properties that reflect their position, formation of subdivisions, neuronal differentiation and level of CAM expression. Using dissociation and reaggregation assays, cells from lateral regions exhibited the largest aggregates while cells from ventral region exhibited small aggregates. Cells from each region also expressed distinct levels of CAMs and other neuronal markers. It is only in the telencephalic region that CAM and neuronal differentiation are most prominent.

Research, Growth, Nervous system, Cell differentiation

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Initial organization of neurons and tracts in the embryonic mouse fore- and midbrain

Article Abstract:

The mechanisms underlying neuronal patterning during development were investigated using lipophilic axon tracers to map neurons in the embryonic mouse fore- and midbrain. Tracts were organized orthogonally and two parallel longitudinal axon projections, one dorsal and the other ventral, were observed. It is suggested that the dorsal axon system subdivides the alar and basal plates along the entire neuraxis. The dorsal-ventral axons were not restricted to interneuromeric boundaries, as has been suggested in previous studies, but crossed the midline to the form the posterior and ventral tegmental commisures.

Usage, Genetic aspects, Brain, Tracers (Biology)

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Pattern formation in the developing mammalian forebrain: selective adhesion of early but not late postmitotic cortical and striatal neurons within forebrain reaggregate cultures

Article Abstract:

Researchers studied, in vitro, the function of cell adhesion in the alignment of like-birthdated neurons inside the rat telencephalon, and monitored the capacity of neurons of similar birthdates to relink with each other inside striatal or cortical reaggregates. Early postmitotic striatal and cortical neurons preferentially link with each other inside their related structures, but do not link in the case of late neurons. The alignment of cortical and striatal neuronal clusters may rely on a common adhesive process that crosses tissue-type boundaries.

Molecular biology, Cell adhesion

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