A long twentieth century of the cell cycle and beyond

Article Abstract:

Important principles underlying the cell cycle, with copying and partitioning of the hereditary material at the center, are reviewed with less emphasis on detailed descriptions of molecular mechanisms and a review going back into the nineteenth century. In the future the whole genome sequences of the budding and fission yeasts will be an important starting point for study. New ways to handle data will be needed. More abstract coneptualization will be needed. Changes will be somewhat like the change of thinking in physics from the Newtonian to relativity and quantum mechanics. The objective should be to see how the overall regulatory network responds to changes in global cellular characteristics, not going upstream.

United Kingdom, History, Achievements and awards, Biologists, Eukaryotic cells, Cells (Biology), Eukaryotes, Biology, Cells, Xenopus, Biological research

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Drosophila p53 is a structural and functional homolog of the tumor suppressor p53

Article Abstract:

Drosophila p53 has been found to be a structural and functional homolog of the tumor suppressor p53. A Drosophila homolog of p53 has been identified. A function contributing to apoptosis has been found for p53. Drosophila is an good model system in which to find out about p53 apoptotic pathways brought on by DNA damage.

United States, Physiological aspects, Cell death, DNA damage, Genetic regulation, Genetic transcription, Transcription (Genetics), Biological models, Tumor suppressor genes, Carcinogenesis

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Regulating S phase: CDKs, licensing and proteolysis

Article Abstract:

DNA replication in the S phase is controlled by the activation of the cyclin dependent kinases (CDKs). The CDK system in this case is composed of a protein kinase catalytic subunit and an activating cylin subunit. Prior to the S phase, a prereplicative complex is formed with the union of the origin recognition complex subunit, the MCM protein subunit and the cdc18/CDC6 subunit. As replication is completed, proteolytic processes requiring the CDC16 and CDC27 proteins act on the cdc18/CDC6 subunit, which switches off the replication machinery.

Proteins, Cellular control mechanisms, Cell regulation

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