Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

Article Abstract:

Researchers have been able to establish that BRCA1/Rad51/BARD1 containing S phase nuclear foci are sensitive to the integrity of the genome. They are subject to significant structural change when exposed to genotoxic insult. BRCA1 seems to relocalize to replicating DNA structures after DNA damage, but the significance of this has not yet been established. It is possible that BRCA1 plays a role in DNA repair, and it could be fully bifunctional, acting as both a factor in the processing of abnormal DNA structures and taking part in the signaling which prompts the activation of genes following DNA damage.

Research, DNA repair, Phosphorylation

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BRCA1, BRCA2, and DNA damage response: collision or collusion?

Article Abstract:

Results of several studies have provided information on the cellular pathways that may be affected by alterations in the breast cancer susceptibility genes BRCA1 and BRCA2. BRCA1 and BRCA2 have been associated with components of DNA damage response pathways resulting from their interaction with human RAD51. Moreover, BRCA1 and BRCA2 respond to DNA damage in several ways, including colocalization, similarities in the chromosomal abnormalities and maintenance.

Analysis, Genetic aspects, Breast cancer

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