The road taken: past and future foundations of membrane traffic

Article Abstract:

Cell membrane traffic is discussed in this review article. Transfer from the ER to endoplasmic reticulum (ER) to the Golgi requires formation of a transport vesicle by a budding event at the donor organelle, the ER, and the later fusion of the carrier at the acceptor organelle, the Golgi. Transport of secretory proteins between distinct organelle compartments is via vesicular carriers. Modern understanding of membrane traffic rests on this concept, but a paradox is created thereby. Underlying mechanisms are controversial although principles governing membrane traffic are now clear. History and future of cell biology are discussed.

United States, Medicine, History, History of medicine, Achievements and awards, Biologists, Carrier proteins, Transport proteins, Heat shock proteins, Cellular control mechanisms, Cell regulation, Cytology, Immunocytochemistry, Membrane fusion, Viral envelopes, Golgi apparatus, Lipids, Lysosomes

---

E. coli hemolysin E (HlyE, ClyA, SheA): X-ray crystal structure of the toxin and observation of membrane pores by electron microscopy

Article Abstract:

X-ray crystal structure of Escherichia coli toxin is discussed Hemolysin E (HlyE) is a novel pore-forming toxin of E. coli and other bacteria. Three-dimensional structure determination of HlyE from E. coli K12 in its putative water-soluble secreted form is reported. So is pore formation in lipid vesicles by electron microscopy. Folding and the nature of HlyE association to form pores in membranes of cells has has been studied.

United Kingdom, Causes of, Escherichia coli, Plasma membranes, Hemolysis and hemolysins, Virulence (Microbiology), Food poisoning, Toxins, X-ray crystallography, Hemolysis

---

Bulk flow redux?

Article Abstract:

Two opposing models were discussed which illustrate the separation of cargo from endoplasmic reticulum (ER) proteins. The first model, called the bulk flow model, illustrates the role of retention and retrieval signals in the movement of ER proteins. It also illustrates the transport of peptides as well as expresses bacterial proteins that are not commonly secreted by eukaryotic cells. The second model, meanwhile, illustrates the role of signals in incorporating cargo molecules into budding COPII vesicles.

Analysis, Membrane proteins

Similar abstracts:

• Abstracts: Comparative study of pressure-induced germination of Bacillus subtilis spores at low and high pressures. Comparative study of pressure- and nutrient-induced germination of Bacillus subtilis spores
• Abstracts: Adhesion of Candida albicans to oral streptococci is promoted by selective adsorption of salivary proteins to the streptococcal cell surface
• Abstracts: act up controls actin polymerization to alter cell shape and restrict hedgehog signaling in the Drosophila eye disc

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.