E2F-1 functions in mice to promote apoptosis and suppress proliferation

Article Abstract:

The E2F transcription factors promote entry into the S-phase of DNA transcription to induce cell proliferation and cellular apoptosis. The disruption of E2F-1 gene in mice did not affect embryonic and reproductive development. Enlargement of the thymus and lymphoid nodes were detected one month after birth. This is caused by the accumulation of mature CD4/CD8 single-positive thymocytes and peripheral T-cells due to a defective pathway of apoptosis. The hyperproliferation of immature thymocytes indicates the importance of E2F-1 as a suppressor of aberrant cell proliferation.

Cell death, Genetic regulation, T cells, Cell proliferation

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A defect in nurturing in mice lacking the immediate early gene fosB

Article Abstract:

Previous research has shown that environmental stimuli that trigger adaptive neuronal responses induce the expression of the Fos family of transcription factors. However, whether Fos family members mediate these responses remains unknown. To resolve this problem, mice with an inactivating mutation in the fosB gene are generated. Results show that complex behavior in mice is controlled by a transcription factor that regulates a specific neuronal circuit. These indicate a genetic component behind nurturing in mammals.

Research, Genetically modified mice, Nurturing behavior

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Association of BRCA1 with Rad51 in mitotic and meiotic cells

Article Abstract:

The BRCA1 and Rad51 proteins were observed to colocalize in vivo and to coimmunoprecipitate. BRCA1 residues 758-1064 alone formed Rad51-containing complexes in vitro. Rad51 is also specifically associated with developing synaptonemal complexes in meiotic cells and BRCA1 and Rad51 were both found on asynapsed elements of human synaptonemal complexes. Therefore, there is a possible functional interaction between BRCA1 and Rad51 in the meiotic and mitotic cell cycles.

Breast cancer, Proteins

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