E2f3 is critical for normal cellular proliferation

Article Abstract:

E2f3, a family of transcription factors regulating cellular proliferation and differentiation, is critical for normal cell proliferation. An E2f3 mutant mouse strain was generated and found to arise at a quarter of the expected frequency. Embryonic fibroblasts from the mutant mice were analyzed. The mutation greatly impairs mitogen-induced transcription activation of cdc2, cdc6 and DHFR. A critical threshold level of one or more of the E2F3-regulated genes determines timing of the G(sub.1)/S transition, rate of DNA synthesis and thus rate of cell proliferation. E2F3 is not necessary for cell immortality but is rate limiting for proliferation of the tumor cell lines that arise from it.

Usage, Cytochemistry, Mice, mutant strains, Mutant mice

---

E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos

Article Abstract:

The E2F transcription factors control gene expression mediating DNA-replication and cell cycle regulation involved in the cellular proliferation process. Research demonstrates that besides E2F1, E2F3 also contributes to the apoptosis and cell proliferation in a significant way.

Cell death, Developmental genetics

---

Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics

Article Abstract:

E2F that directly participates in the transcriptional control of Arf in both normal and transformed cells is shown. It is proposed that monitoring of E2F levels and activity is a key component of Arf's ability to respond to inappropriate, but not cellular proliferation.

Science & research, Tumor suppressor genes, Tumour suppressor genes

Similar abstracts:

• Abstracts: act up controls actin polymerization to alter cell shape and restrict hedgehog signaling in the Drosophila eye disc
• Abstracts: Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice
• Abstracts: A novel thermostable multidomain 1,4-beta-xylanase from 'Candibacillus cellulovorans' and effect of its xylan-binding domain on enzyme activity
• Abstracts: Genetic structure and affinities of the Corsican population (France): classical genetic markers analysis. Mitochondrial control-region sequence variation in the Corsican population, France
• Abstracts: Crystal structure of the cytoplasmic domain of the type I TGFbeta receptor in complex with FKBP12. Controlling TGF-beta signaling

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.