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Emilin1 links TGF-beta maturation to blood pressure homeostasis

Article Abstract:

An unprecedented link between TGF-beta signaling and arterial hypertension is reported based on the analysis of mice mutant for Emilin1, as cysteine-rich secreted glycoprotein expressed in the vascular tree. The study highlights the importance of modulation of TGF-beta availability in the pathogenesis of hypertension.

Author: Marino, Gennaro, Vecchione, Carmine, Cordenonsi, Michelangelo, Maretto, Silvia, Piccolo, Stefano, Selvetella, Giulio, Maffei, Angelo, Zacchigna, Luca, Soligo, Sandra, Adorno, Maddalena, Ferrari, Alessandra, Notte, Antonelia, Dupont, Sirioo, Cifelli Giuseppe, Fabbro, Carla, Braghetta, Paola, Russo Giovanni, Volpin, Dino, Lembo, Guiseppe, Bressan, Giorgio M., Aretini, Alessandro, Colonese, Claudio, Bettarini, Umberto
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
Mice, mutant strains, Mutant mice, Homeostasis, Cysteine

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Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase

Article Abstract:

Ecto is a RING-type ubiquitin ligase for Smad4, a TGF-beta signal transducer. It is proposed that Ectodermin is a key to switch in the control of TGF-beta gene responses during early embryonic development and cell proliferation.

Author: Cordenonsi, Michelangelo, Dupont, Sirio, Rugge, Massimo, Zacchigna, Luca, Soligo, Sandra, Adorno, Maddalena, Piccolo Stefano
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
Ubiquitin, Endoderm

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Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads

Article Abstract:

Research has been conducted on p53 tumor suppressor which regulates cell proliferation, differentiation and apoptosis. The authors demonstrate that p53 can physically interact with Smad2 in TGF-beta-dependent manner.

Author: Cordenonsi, Michelangelo, Dupont, Sirio, Maretto, Silvia, Insinga, Alessandra, Imbriano, Carol, Piccolo, Stefano
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
Italy, Physiological aspects, Genetic aspects, Proteins, Tumor suppressor genes, Cell research, Cytological research, Apoptosis, Tumour suppressor genes

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Subjects list: Research, Analysis, Cell proliferation
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