End-product control of expression of branched-chain amino acid biosynthesis genes in Streptomyces coelicolor A3(2): paradoxical relationships between DNA sequence and regulatory phenotype

Article Abstract:

Branched-chain amino acid biosynthesis genes in Streptomyces coelicolor A3(2) are discussed relative to end-product control of their expression. Paradoxical relationships have been observed between DNA sequence and the regulatory phenotype. The branched-chain protein amino acids of interest are leucine, isoleucine and valine and they can give precursors for synthesis of complex polyketide secondary metabolites in streptomycetes.

United Kingdom, Genetic regulation, Genetic transcription, Transcription (Genetics), Biosynthesis, Leucine, Branched chain amino acids, Isoleucine

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Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production

Article Abstract:

Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces avermitilis and Streptomyces coelicolor are discussed. They give insights into metabolism of macrolide antibiotic production and small branched-chain fatty acids. S. coelicolor and S. avermitilis genes encoding an acyl-CoA dehydrogenase thought to be involved in the catabolism of branched-chain amino acids were cloned.

United States, Usage, Isotopes, Chromosome mapping, Biology, Amino acids, Radioactive tracers, Radioactive tracers in biology

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