Major histocompatibility complex (MHC) variation in the endangered Mexican wolf and related canids

Article Abstract:

The amount of genetic variation for a class II gene in the major histocompatibility complex has been studied in the Mexican wolf, an endangered species, and related canids. It is thought to be part of the most important genetic basis for pathogen resistance in vertebrates. For Mexican wolves five different alleles were found. One of the Mexican wolf alleles was found in dogs and the allele found in grey and red wolves is found in dogs.

Mexico, Environmental aspects, Endangered species, Wolves, Phylogeny, Dogs, Histocompatibility, Canidae, Canids

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Is the decline of desert bighorn sheep from infectious disease the result of low MHC variation?

Article Abstract:

Decline of desert bighorn sheep in the Western United States since European settlement is discussed. It has been caused by infectious disease, which may be the result of low major histocompatibility complex (MHC) variation. It appears, based on examination of variation, that MHC variation for the DRB gene is not the cause of the decline.

Diseases, Biological diversity, Biodiversity, Major histocompatibility complex, Desert ecology

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Estimation of linkage disequilibrium for loci with multiple alleles: basic approach and an application using data from bighorn sheep

Article Abstract:

The basic approach of a study to estimate linkage disequilibrium for loci with multiple alleles is discussed and applied to data from bighorn sheep. Haplotype frequencies for all pairwise combinations of five major histocompatibility loci and three microsatellite loci in 14 populations were calculated. High levels of disequilibrium were seen between all pairs of major histocompatibility complex (MHC) loci and between MHC and a linked microsatellite locus. The algorithm and its performance are discussed.

Reports, Genetic research, Linkage (Genetics)

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• Abstracts: Heritability of body mass varies with age and season in wild bighorn sheep. Quantitative genetics of life-history traits in a long-lived wild mammal

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