Evidence that a locus for familial high myopia maps to chromosome 18p

Article Abstract:

A genomewide screen has been carried out to map genes associated with early-onset high, autosomal dominant myopia. Eight families made up of 82 subjects, were identified and DNA was available for 71, of whom 37 were affected. For markers for The Marfan syndrome, the Stickler syndrome types 1 and 2, or the juvenile glaucoma loci no evidence of linkage was found. Evidence of significant linkage exists on chromosome 180.

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A second locus for familial high myopia maps to chromosome 12q

Article Abstract:

A second locus for familial high myopia, a locus that maps to chromosome 12q, at the 12q21-23 region, is discussed. A large German-Italian family with no clinical evidence of connective-tissue abnormalities or glaucoma, but in which the average age at myopia diagnosis is 5.9 years, was studied and heterogeneity was shown.

Statistical Data Included, Abnormalities, Eye, Eye abnormalities

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