Evidence that loading of cohesin onto chromosomes involves opening of its SMC hinge

Article Abstract:

Cohesin's hinges are not just dimerization domains, as they are essential for cohesin's association with chromosomes, which is blocked by artificially holding hinge domains together but not by preventing Scc1's dissociation from SMC ATPase heads. The results have indicated that entry of DNA into cohesin's ring requires transient dissociation of Smc1 and Smc3 hinge domains.

Analysis, Chromosomes, Adenosine triphosphatase, Dissociation, Dissociation reactions, ATPases, Report

---

Retrospective birth dating of cells in humans

Article Abstract:

An attempt is made to show that the level of (super 14)C in genomic DNA closely parallels atmospheric levels in genomic and can be used to establish the time point when the DNA was synthesized and cells were born. Retrospective birth dating is an applicable strategy that can be used to measure cell turnover in man under physiological and pathological conditions.

Genetic research, Human genome

---

Mapping the location of TFIIB within the RNA polymerase II transcription preinitiation complex: a model for the structure of the PIC

Article Abstract:

Biochemical probes were used to probe the architecture of RNA polymerase II (POl II) transcription preinitiation complex (PIC). Specific interaction of the TFIIB core domain with POl II position orients the promoter DNA.

Genetic transcription, Transcription (Genetics), RNA polymerases

Similar abstracts:

• Abstracts: Identification of Listeria monocytogenes genes involved in salt and alkaline-pH tolerance. Involvement of the reserve material poly-beta-hydroxybutyrate in Azospirillum brasilense stress endurance and root colonization
• Abstracts: Patterns of microsatellite variation through a transition zone of a chromosomal cline in Drosophila americana
• Abstracts: Lateral and axial signals involved in avian somite patterning: a role for BMP4. The divergent robo family protein Rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons
• Abstracts: The preprotein translocation channel of the outer membrane of mitochondria. The YTA10-12 complex, an AAA protease with chaperone-like activity in the inner membrane of mitochondria
• Abstracts: Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.