Extracellular and surface-exposed polysaccharides of non-tuberculous mycobacteria

Article Abstract:

Comparison of the extracellular materials (ECMs) and the surface-exposed materials (SXMs) of five pathogenic and non-pathogenic mycobacterial species reveals that the glycosyl composition of the ECMs and SXMs in a given species are similar. However, the SXMs of M. avium and M. phlei lack arabinose and their polysaccharides lack arabinomannans. Anion-exchange and gel-filtration chromatography indicate that the polysaccharides in the materials are neutral. The polysaccharides of ECMs consist of glycogen-like glucans, mannans and arabinomannans of high molecular mass.

Analysis, Polysaccharides

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The outermost capsular arabinomannans and other mannoconjugates of virulent and avirulent tubercle bacilli

Article Abstract:

The occurrence and structure of the outermost mannoconjugates of the capsule of five strains of the tubercle bacillus differing in their degrees of virulence were studied. The extracellular and surface-exposed arabinomannan-containing polysaccharides were found to be made mostly of neutral fatty-acyl-free arabinomannans with a reducing end made of mannose. Findings indicated that mannosylated molecules are not involved in the selective phagocytosis of virulent tubercle bacilli.

Tuberculosis

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Mechanisms of pyrazinamide resistance in mycobacteria: importance of lack of uptake in addition to lack of pyrazinamidase activity

Article Abstract:

A study was conducted to analyze the uptake mechanism of the antituberculosis drug, pyrazinamide, in Mycobacterium tuberculosis. Results indicated that one of the mechanisms of resistance to pyrazinamide resides in the failure of strains to take up the drug. Findings also showed that susceptibility to the drug in mycobacteria requires the presence of a functional PZase and a PZA transport system.

Antitubercular agents, Pyrazinamide

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