Point and interval estimates of marker location in radiation hybrid mapping

Article Abstract:

Interval and point estimates of marker location are discussed as they relate to radiation hybrid (RH) mapping, a powerful method for ordering loci on chromosomes and estimating distances between them used to set up framework and comprehensive maps. A statistical method for estimating marker position, an alternative to binning, is proposed, a method combining a measure of uncertainly in location for every marker and information from all plausible marker orders.

Methods, Analysis, Bayesian statistical decision theory, Bayesian analysis, Genetic markers, Mammals, Chromosomes, Probabilities, Probability theory, Markov processes

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A comparative study of sibship tests of linkage and/or association

Article Abstract:

An extension of one of three recently developed family-based tests of association and linkage using unaffected siblings as surrogates for untyped parents is proposed. The four tests are then compared using as an example the application to a complex disease for both biallelic and multiallelic markers and for sibships of varying sizes, then looking at availability of some parental data.

Genetic disorders, Population genetics, Familial diseases, Monte Carlo method, Monte Carlo methods, Brothers and sisters, Linkage (Genetics)

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