Hearts and bones: shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development

Article Abstract:

A study to understand the specific regulatory pathways that help in the heart valve development along with the development of cells in connective tissues like cartilage, tendon, and bones, is presented.

Physiological aspects, Cellular control mechanisms, Cell regulation, Connective tissues, Connective tissue

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NFATc1 expression in the developing heart valves is responsive to the RANKL pathway and is required for endocardial expression of cathepsin K

Article Abstract:

Role of nuclear factor of activated T-cells in heart valve leaflet morphogenesis and endocardial expression of receptor activator of NF?B ligand is presented.

Morphogenesis, Cathepsins

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BMP and FGF regulatory pathways control cell lineage diversification of heart valve precursor cells

Article Abstract:

Regulation of heart valve progenitor cell diversification by fibroblast growth factor 4 and bone morphogenetic protein 2 is analyzed.

Influence, Fibroblast growth factors, Bone morphogenetic proteins

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