Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family

Article Abstract:

Construction of genetic screens has revealed that a member of the tumor necrosis factor/nerve growth factor receptor family mediates herpes simplex virus-1 (HSV-1) penetration into cells. Designated the herpesvirus entry mediator (HVEM), this receptor was shown to enhance the entry of HSV-1 and HSV-2 strains into infected CHO-K1 and ST cell lines by interacting with one or more of the virion envelope glycoproteins. Infection was inhibited by anti-HVEM antibodies or HVEM:Fc as a result of direct interaction with virion surface proteins.

Genetic aspects, Tumor necrosis factor, Herpes simplex virus, Nerve growth factor

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Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability

Article Abstract:

Axons in the nervous systems of vertebrates are sheathed with the multilamellar membrane myelin, which is enriched with the galactolipid galactocerebroside (GalC) and its sulfated derivative sulfatide. In the case of mice lacking the required enzyme for GalC synthesis, myelin containing glucocerebroside is formed. However, the myelin formed, while of normal appearance, exhibit reduced insulative capacity and severe generalized tremoring and mild ataxia. These indicate the importance of GalC and sulfatide in myelination.

Research, Myelination, Myelin sheath

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