Human pedigree-based quantitative-trait-locus mapping: localization of two genes influencing HDL-cholesterol metabolism

Article Abstract:

Genes located on chromosome 8 and chromosome 15 appear to influence HLD-cholesterol metabolism., according to results of a full genomic scan. Multivariate analyses indicate that the locus on chromosome 8 affects unesterified cholesterol levels, while the locus on chromosome 15 affects concentration of HDL-cholesterol as well as how cholesterol is distributed among different particle sizes of HDL. Data were derived from Mexican American families in the San Antonio Family Heart Study.

Physiological aspects, Cholesterol, HDL, HDL cholesterol lipoproteins, Cholesterol metabolism

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Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans

Article Abstract:

Studies support the location of type 2 diabetes susceptibility in Mexican Americans on chromosome 10q. Using a variance-components process to perform multipoint linkage analyses on 440 Mexican American subjects, researchers found a susceptibility locus near the D10S587 marker that not only influences type 2 diabetes but age at onset as well.

United States, Health aspects, Research, Diabetes, Diabetes mellitus, Mexican Americans, Chromosome abnormalities

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