IRAK-M is involved in the pathogenesis of early onset persistent asthma

Article Abstract:

Affected Sardinian families were studied to elucidate the genetic components of asthma by linkage and association analysis at chromosome 12q13-24. It was found that variants in the interleukin-1 receptor associated kinase-M gene are associated with early-onset persistent asthma and indicate interleukin-1 receptor associated kinase-M gene as a potential target for therapeutic intervention against asthma.

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Sequence-based prioritization of nonsynoymous single-nucleotide polymorphisms for the study of disease mutations

Article Abstract:

A bioinformatics approach that uses a novel statistical learning model (MSRV) with a set of improved sequence-based numeric feature to effectively prioritize candidate nsSNPs occurring in genetic regions is discussed.

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