IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development

Article Abstract:

Research has been conducted on B-lymphocyte development which involves DNA rearrangements of immunoglobulin heavy and light chain loci. The authors report that B-cell development is arrested at the cycling pre-B-cell stage, and they propose that interferon regulatory factors-4,8 function as genetic switch to down-regulate surrogate light-chain gene expression and induce conventional light-chain gene transcription.

Biological Product (except Diagnostic) Manufacturing, Drugs, Biological products exc. diagnostic, Deoxyribonucleic Acid, Interferon, Analysis, Physiological aspects, Genetic aspects, DNA, Gene expression, Genetic transcription, Transcription (Genetics), Immunoglobulins, B cells, Lymphocytes, Genetic research

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Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4

Article Abstract:

A study carried out on the histone deacetylase 3 (HDAC3) activity that is regulated by both phosphorylation and dephosphorylation in addition to protein-protein interaction with the corepressors N-CoR and SMRT. The findings highlight the importance of the protein-protein interactions and extend the significance of dephosphorylation in the regulation of HDAC activity.

Science & research, Research, Histones, Phosphorylation

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