Identification of clonogenic common lymphoid progenitors in mouse bone marrow

Article Abstract:

There is still controversy over the existence of a common lymphoid progenitor that can give rise only to T or B cells and natural killer (NK) cells. It is reported that the Lin-IL-7R+Thy-1Sca-1super10c-Kitsuper10 population in adult mouse bone marrow, has a rapid lymphoid-restricted reconstitution capacity in vivo, although lacked myeloid differentiation potential in vivo or in vitro. This provides evidence for the existence of common lymphoid progenitors in early hematopoiesis.

Observations, Cell research, Cytological research, Hematopoietic agents

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Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice

Article Abstract:

A study was conducted on the enforced expression of Bcl-2 in monocytes to determine whether these Bcl-2-expressing monocytes undergo macrophage differentiation to reverse osteopetrosis in osteopetrotic mice. Results reveal that after subjects were exposed to Bcl-2 monocytes, their long bone osteopetrosis were significantly reversed. Furthermore, macrophage colony-stimulating factors are responsible for external and internal response to such differentiations.

Genetic aspects, Macrophages, Monocytes, Genetically modified mice, Osteopetrosis

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Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice

Article Abstract:

The influence of Bcl-2 gene in the mediation of T lymphopoiesis in interleukin-7 receptor-deficient mice was investigated through introduction of Emicron-bcl-2 transgene in T lineage cells. Results have shown that Bcl-2 in T lineage cells mediate T cell functional maturation in IL-7 receptoralpha(super -l-). Furthermore, it is indicated that Emicro-bcl-2 transgene can induce thymocyte development in IL-7Ralpha receptor(super -l-).

Growth factors, Antigen receptors, T cell, T cell antigen receptors, Interleukins, T cells

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