In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism

Article Abstract:

A study analyzes the distribution of viral RNA within a nucleus and the response of the host cell RNA processing apparatus to the introduction of new active transcription sites. Meanwhile, Ad2 infection is utilized as a model system to prove that the spatial-temporal relationship between transcripts and pre-mRNA splicing in infected cell nuclei is very close. This is due to a presence of localization and the shuttling of splicing factors to new sites of active transcription. Thus, there is the possible existence of a recruiting mechanism which enables the cell to coordinate these events.

Genetic transcription, Transcription (Genetics)

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Nonsense mutations inhibit RNA splicing in a cell-free system: recognition of mutant codon is independent of protein synthesis

Article Abstract:

Research indicates that the accumulation of mutated strains of RNA (Ribonucleic acid) amino acids depletes the m(messenger)RNA content reducing the occurrence of RNA splicing. This mutation can be corrected by changing the methionine sequence of the RNA. Protein generation does not affect the detection of nonsense or mutated codons if this process occur in the absence of cells. Codon mutations are not detected in T lymphocytes. The presence of RNA mutants occurs only in beta cells indicating that codon mutation is found only in specific genetic locations.

Physiological aspects, Mutation (Biology), Mutation, Messenger RNA

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Systematic identification and analysis of exonic splicing silencers

Article Abstract:

Exonic splicing silencers (ESSs), which are cis-regulatory elements prohibiting the use of splice sites that are adjacent, and can be identified as in vivo splicing reporters was developed. The different roles of ESSs in constitutive splicing were explored using ExonScan, and it was found that ESS motifs are important in suppression of pseudoexons in splice site definition.

Science & research, Exon (Molecular genetics), Exons (Molecular genetics)

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