Increased neutrophil respiratory burst in bcr-null mutants

Article Abstract:

A study of the role of Bcr protein in normal and leukemic cells using bcr-null mutant mice reveals that gram-negative endotoxin exposure results in septic shock and enhances tissue injury due to neutrophils. Reactive oxygen metabolite synthesis following the stimulation of neutrophils is enhanced in bcr (-/-) mice. P21(rac2) membrane translocation is 3 times higher in stimulated (-/-) neutrophils than in (+/+) neutrophils, indicating that in vivo regulation of Rac involves Bcr at the time of neutrophil priming and activation, and the regulation is related to the cell types involved in Ph-positive leukemia.

Research, Analysis, Proteins, Mutation (Biology), Mutation

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Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4

Article Abstract:

A study was conducted to determine the physiological roles of CHICO, an adaptor protein homologous to vertebrate insulin receptor substrates, and the Drosophila insulin receptor gene. Results suggest that CHICO and the insulin receptor gene, combined with the perturbations of insulin/insulin-like growth factor 1 signalling pathway, play essential roles in regulating cell proliferation, cell size and overall body growth

Cells (Biology), Growth, Cells, Drosophila, Cell receptors, Insulin-like growth factors, Somatomedins, Cell metabolism

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E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

Article Abstract:

Results show that differentiation of adipocytes and neutrophil granulocytes and their proliferation is controlled by the transcription factor C/EBPalpha, which represses E2F. C/EBPalpha mutants defective in E2F repression activity are unable to suppress cellular proliferation.

Denmark, Granulocytes, Adipose tissues, Adipose tissue

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