Induction of the LIM homeobox gene Lmx1 by WNT7a establishes dorsoventral pattern in the vertebrate limb

Article Abstract:

The establishment of the dorsoventral (DV) axis in vertebrate limbs during embryogenesis is controlled by the Wnt7a protein stimulation of the Lmx1 homeobox gene in the limb mesenchyme. Ectopic expression of Lmx1 in the ventral mesoderm due to the ectopic Wnt7a expression causes limb defects, especially duplication of the limbs. This is probably due to the induction of the Shh gene.

Genetic aspects, Gene expression, Homeobox genes, Extremities (Anatomy)

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Type II cadherin ectodomain structures: Implications for classical cadherin specificity

Article Abstract:

A study is conducted to identify the crystal structures of extracellular domains from three type II cadherins, MN-cadherin, cadherin-8, and cadherin-11. The findings reveal that the extracellular cadherin-1 (EC1) domain of type II cadherins, which encodes the adhesive interface identified crystallographically, is a dominant element in determining functional specificity in vivo.

Science & research, Membrane proteins, Cell interaction, Cell interactions, Cell adhesion

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Coordinate roles for LIM homeobox genes in directing the dorsoventral trajectory of motor axons in the vertebrate limb

Article Abstract:

Research demonstrates that initial trajectory regulation of motor axons is mediated by two transcription factors Lim1 and Lmx1b in the developing mammalian limb. Data indicate that axons of the Lim1 choose dorsal trajectory and that of Lmx1b selects dorsal and ventral axonal trajectories of lateral motor column neurons.

Physiological aspects, Vertebrates, Developmental biology, Axons, Neurons

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