Integrins alphavbeta3 and alphavbeta5 promote adenovirus internalization but not virus attachment

Article Abstract:

Adenoviruses attach to cells via a 186-kd fiber protein and a 400-kd penton base that contains five Arg-Gly-Asp sequences. The Arg-Gly-Asp sequence mediates cell adhesion through heterodimeric cell surface receptors called integrins. A study was conducted to differentiate the process of viral attachment from subsequent internalization. Results showed that antibodies against vitronectin-binding integrins alphavbeta3 and alphavbeta5 prevent virus internalization without affecting attachment. Thus, integrins alphavbeta3 and alphavbeta5 promote adenovirus internalization.

Viruses, Virus receptors

---

Role of alpha v integrins in adenovirus cell entry and gene delivery

Article Abstract:

A study has been conducted to discuss the earliest interactions of the adenovirus with its cellular receptors and to investigate the role of the virus internalization receptors, integrins alpha v beta 3 and alpha v beta 5. Integrins have been known to promote adenovirus entry both in vitro and in vivo environments. Findings have indicated that while integrins are required for virus penetration, they are necessarily sufficient. Some other elements may have to be present to complete the invasion process.

Development and progression, Gene expression, Adenovirus diseases, Adenovirus infections

---

Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity

Article Abstract:

Research was conducted to study the disruption of angiogenesis by a fragment of matrix metalloproteinase 2 (MMP-2) called PEX. Fusion proteins were prepared using primers based on the avian MMP-2 sequence. Results indicated that MMP-2 localizes in a proteolytically active form on the surface of invasive cells based on its ability to bind integrin alpha-v-beta-3. They also showed that PEX blocks MMP-2 binding to alpha-V-beta3, resulting in a loss of cell-associated collagenolytic activity.

Analysis, Proteins, Neovascularization, Metalloenzymes

Similar abstracts:

• Abstracts: Interspecific pollen competition and reproductive isolation in Iris. Age-specific fitness components in hybrid females of Drosophila pseudoobscura and D. persimilis
• Abstracts: Effects of specific inhibitors on anammox and denitrification in marine sediments. Measurement of denitrification in sediments with the (super)15 N isotope pairing technique
• Abstracts: The influence of male part body size and mate competition on fertilization success and effective population size in Atlantic salmon
• Abstracts: Laysan Finch nest characteristics, nest spacing and reproductive success in two vegetation types. The breeding biology of an endangered Hawaiian honeycreeper, the Laysan Finch
• Abstracts: Bacteriophage inactivation at the air-water-solid interface in dynamic batch systems. VIRTUS, a model of virus transport in unsaturated soils

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.