Kappa chain monoallelic demethylation and the establishment of allelic exclusion

Article Abstract:

Demethylation may be the basis for allelic exclusion in kappa light-chain synthesis. It may direct the first choice of a single kappa allele for rearrangement. Demethylation initiated at the small pre-B cell stage on one allele seems to generate the observed pattern of kappa-plus B-cell rearrangement in which certain sites on the rearranged allele are unmethylated while the allele that is not rearranged is still methylated. The process of demethylation takes place before rearrangement and the presence in cis of the intronic and 3' kappa enhancers is necessary.

Genetic aspects, Immunoglobulins, Allelomorphism, Alleles, Lymphocytes, Methylation

---

Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene

Article Abstract:

The ectopic Pax5 expression from the Ikaros promoter that induces proximal rather than distal V(sub H) -DJ(sub H) rearrangements in IK(super Pax5/+) is demonstrated. The conclusion states that Pax5 activates locus contraction and distal V(sub H) -DJ(sub H) rearrangements in collaboration with an unknown factor that is present in pro-B cells but absent in thymocytes.

Gene expression, Immunoglobulin genes

---

Yin Yang 1 is a critical regulator of B-cell development

Article Abstract:

The transcription factor Yin Yang 1(YY1) binds to the heavy-chain of immunoglobulin causing the latter to contract. This leads to recombination of variable, diversity and joining genes that is crucial for regulation of B-cell development.

Genetic transcription, Transcription (Genetics)

Similar abstracts:

• Abstracts: Tailored Hox gene transcription and the making of the thumb. Polycomb mediates Myc autorepression and its transcriptional control of many loci in Drosophila
• Abstracts: FGF can induce outgrowth of somatic mesoderm both inside and outside of limb-forming regions
• Abstracts: Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation
• Abstracts: Docosahexaenoic acid, the aquatic diet, and hominin encephalization: Difficulties in establishing evolutionary links
• Abstracts: On the trail of a point mutation: The discovery of a blood-cancer gene raises tantalizing questions

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.