Activin receptor patterning of foregut organogenesis

Article Abstract:

Activin receptor patterning is discussed relative to foregut organogenesis. Mutations of activin receptors ActRHA and Act RIIb can be seen to disrupt the development of posterior foregut-derived organs. The conclusion is that activin-receptor mediated signaling regulates axial patterning, cell differentiation, and function of foregut-derived organs.

United States, Physiological aspects, Proteins, Cellular signal transduction, Cell receptors, Gastrointestinal system

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Krox-20 patterns the hindbrain through both cell-autonomous and non cell-autonomous mechanisms

Article Abstract:

Krox-20 expression has been shown to be adequate to confer odd-numbered rhombomere characteristics to r6, r4 and r2 cells, likely in a cell-autonomous way. Krox-20 was expressed ectopically in the developing chick hindbrain using electroporation. It seems Krox-20 is an important determinant of odd-numbered identity in the hindbrain. Evidence for existence of a non cell-autonomous autoactivation mechanism making recruitment of Krox-20- positive cells from even-numbered territories by neighboring Krox-20-expressing cells possible has been found. Likely Krox-20 contoles multiple, intertwined steps in segmental patterning.

France, Vertebrates, Genetic transcription, Transcription (Genetics), Neurogenetics, Chick embryo

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Notochord repression of endodermal Sonic hedgehog permits pancreas development

Article Abstract:

Notochord factors activin-BB and FGF2 repress endodermal Sonic hedgehog (SHH) and allow pancreatic gene expression. This includes Pdx1 and insulin. This is a contrast to the role notochord plays in inducing SHH in the neuroectoderm. Intercellular signals that can block SHH expression in prepancreatic dorsal endoderm can help the development of chick pancreas.

Pancreas, Fibroblast growth factors

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