Laboratory-directed protein evolution

Article Abstract:

Several successful strategies in creating protein diversity and the progress in directed protein evolution in a wide range of scientific disciplines and its impacts in chemical, pharmaceutical, and agricultural sciences are reviewed. Focus is laid on the directed evolution of proteins through gradual accumulation of beneficial mutations, and examples of recombination-based approaches are used primarily to illustrate the power of this technology.

United States, Science & research, Pharmaceutical research

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Mechanisms of T-cell activation by human T-cell lymphotropic virus type I

Article Abstract:

The interactions between the cellular immune system and human T-cell lymphotropic virus type I can be categorized into viral interference supporting functions of the infected host T cell and the resulting interactions between the infected T cell and the cellular immune system. Results of several studies indicated that Tax may promote G1- to S-phase transitions which may also involve additional proteins.

T cells, Cellular immunity

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