Loss-of-function mutations in growth differentiation factor-1 (GDF1) are associated with congenital heart defects in humans

Article Abstract:

Study is conducted to show that heterozygous loss-of-function mutations in the human GDF1 gene contribute to cardiac defects ranging from tetralogy of Fallot to transposition of the great arteries. The findings implicate perturbations of the TGF-[beta] signaling pathway in the causation of a major subclass of human congenial heart defects (CHDs).

Heart diseases, Growth factors

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Significant correction of disease after postnatal administration of recombinant ectodysplasin A in canine X-linked ectodermal dysplasia

Article Abstract:

The postnatal administration of (defective ectodysplasin A) Fc:EDA1 in dogs that has a prominent effect on permanent dentition and significantly improves long-term resistance to eye and airway infections through restoration of glandular functions are demonstrated.

Health aspects, Dogs, Dentition, Ectodermal dysplasia

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