Mitotic remodeling of the replicon and chromosome structure

Article Abstract:

Animal cloning by nuclear-transfer experiments fails frequently due to inability of transplanted nuclei to support normal embryonic development. Results indicate that mitotic conditioning is crucial to reset the chromatin structure of differentiated adult donor cells from embryonic DNA replication.

United States, Cloning, Mitosis, Cell nuclei, Cell nucleus

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MCM8 is a MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation

Article Abstract:

The MCM2-7-related protein MCM8 is required to efficiently replicate chromosomal DNA in Xenopus egg extracts. Reconstitution experiments show that ATP binding in MCM8 is required to rescue DNA synthesis in MCM8-depleted extracts.

Genetic aspects, Xenopus, Protein research

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MCM8 is a MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation

Article Abstract:

The MCM2-7-related protein MCM8 is required to efficiently replicate chromosomal DNA in Xenopus egg extracts. Reconstitution experiments show that ATP binding in MCM8 is required to rescue DNA synthesis in MCM8-depleted extracts.

Protein binding, Adenosine triphosphate, ATP, DNA synthesis

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