MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation

Article Abstract:

The search for possible protein partners that interact with the Ets-1 protein in its regulatory activities identified MafB, a bZip protein of the Maf family. MafB interacts with Ets-1 to inhibit the transactivation of the transferrin receptor by Ets-1, resulting in the repression of erythroid differentiation. MafB links with Ets-1 by binding to the DNA-binding domain via its basic region or leucine-zipper domain.

Genetic aspects, Proteins, Genetic regulation, Gene expression, Cell differentiation

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Autophagy is a defense mechanism inhibiting BCG and mycobacterium tuberculosis survival in infected macrophages

Article Abstract:

Mycobacterium tuberculosis is an intracellular pathogen that exists in phagosomes through interference with phagolysosome. Tests were conducted to show that stimulation of autophagic pathways makes mycobacterial phagosomes to mature into phagolysosomes and authophagy, which is an immunologically regulated process, acting as a defense mechanism that controls intracellular pathogens.

Science & research, Risk factors, Mycobacterium tuberculosis, Macrophages, BCG

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