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Mammalian origins of replication

Article Abstract:

Several novel approaches have been developed to investigate whether mammalian origins of replication are defined sequence elements as found in prokaryotes. In vitro and in vivo labelling procedures have been devised to identify and/or isolate nascent or recently replicated DNA. In addition, dihydrofolate reductase (DHFR) locus cross linking studies have been conducted to identify replication initiation sites. With the recent discovery of inhibitors that produce synchronized mammalian cell populations, the elucidation of the DHFR initiation locus' nature will undoubtedly be forthcoming.

Author: Hamlin, Joyce L.
Publisher: John Wiley & Sons, Inc.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 1992
Usage, Cytology, Mammals, Dihydrofolate reductase, Tetrahydrofolate dehydrogenase

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On the nature of origins of DNA replication in eukaryotes

Article Abstract:

Studies have revealed that four chromosomal replication origin regions in higher eukaryotes commonly share modular sequence elements such as DNA unwinding elements, pyrimidine tracts, scaffold-associated regions and transcriptional regulatory sequences. Initiator protein binding sites and inherently destabilized regions might also possibly be shared. A DNA replication initiation model which postulates uncoupled DNA duplex unwinding, transient single stranded intermediates and DNA synthesis at multiple sites is proposed.

Author: Zhao, Jiyong, Benbow, Robert M., Larson, Drena D.
Publisher: John Wiley & Sons, Inc.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 1992
Eukaryotic cells, Cells (Biology), Eukaryotes

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Accessory protein function in the DNA polymerase III holoenzyme from E. coli

Article Abstract:

Chromosome replication in Eschericia coli is dependent on the activity of the multiprotein complex Deoxyribonucleic Acid (DNA) polymerase III holoenzyme. This replicase is composed of a DNA polymerase subunit and nine accessory proteins with discrete functions in 3'-5' exonuclease proofreading and DNA replication and synthesis. These are attributed to the epsilon, beta, tau, gamma and epsilon subunits, respectively.

Author: O'Donnell, Mike
Publisher: John Wiley & Sons, Inc.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 1992
Escherichia coli, DNA polymerases

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Subjects list: Research, DNA, Chromosome replication, Genetic aspects
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