Mapping of X-linked myxomatous valvular dystrophy to chromosome Xq28
Article Abstract:
X-linked myxomatous valvular dystrophy (XMVD), a rare myxoid heart disease characterized by multivalvular myxomatous degeneration, has been mapped to chromosome Xq28. Myxoid heart disease overall is not rare and corresponds to an etiologically heterogeneous group of diseases, idiopathic mitral valve prolapse being the most common. A large family in which XMVD was found with a mild hemophilia A has been subjected to genetic analysis. The coagulation factor VIII gene position in Xq28 gave a starting point.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
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Genetic linkage of hereditary gingival fibromatosis to chromosome 2p21
Article Abstract:
Hereditary gingival fibromatosis (HGF) is usually an autosomal dominant trait, although autosomal recessive inheritance is reported and sporadic cases are common. HGF is the most common form of gingival fibromatosis and has been linked to chromosome 2p21. Finding may lead to discovery of the underlying genetic basis of gingival fibromatosis.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
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