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Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal

Article Abstract:

Methylation's role in imprinting is studied by viewing parental-specific methylation patterns at the mouse Igf2r locus in male and female gametes, in the embryo and in the adult. Specifically, it is determined whether the locus has methylation modifications that could function as the imprinting signal which makes the cell's transcription process differentiate between genetically identical parental loci and limit expression to the maternal locus. It is concluded that germline methylation of a specific region within the maternal locus may be necessary for the Igf2r gene to be imprinted.

Author: Stoger, R., Kubicka, P., Liu, C.G., Kafri, T., Razin, A., Cedar, H., Barlow, D.P.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
Growth factor receptors, Methylation

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Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification

Article Abstract:

The relationship of the ubiquitin pathway in chromatin dynamics and male infertility was investigated. Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice caused male infertility. The defect in spermatogenesis was associated with postmeiotic chromatin remodeling. These results suggested that ubiquitination in chromatin remodeling may be associated with male infertility in mice.

Author: Bootsma, D., Hoeijmakers, J.H.J., Roest, H.P., Van Klaveren, J., De Wit, J., Van Gurp, C.G., Koken, M.H.M., Vermey, M., Van Roijen, J.H., Hoogerbrugge, J.W., Vreeburg, J.T.M., Baarends, W.M., Grootegoed, J.A.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
Genetic aspects, Mice, Mice (Rodents), Chromatin, Ubiquitin, Fertility

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Looping, linking, and chromatin activity: new insights into beta-globin locus regulation

Article Abstract:

Research on the locus control region (LCR) of the embryonic epsilon-globin gene is discussed. The LCR has little influence on chromatin sensitivity, but chromatin structure can affect nonglobin transcription within LCR.

Author: Engel, James Douglas, Tanimoto, Keiji
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
Globin genes

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