Matrix elasticity directs stem cell lineage specification
Article Abstract:
Studies related to naive mesenchymal stem cells (MSCs) which specify lineage and commit to phenotypes with extreme sensitivity to tissue level elasticity is described. The findings suggest that reprogramming to lineages is possible with addition of soluble induction factors, but after several weeks in culture, the cells commit to the lineage specified by matrix elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Matrix control of stem cell fate
Article Abstract:
The effects of matrix compliance on human mesenchymal stem cells were quantified by microarray analyses. The results revealed that soft matrices favored differentiation of mesenchymal stem cells into neuronal-like cells, moderate elasticity promoted myogenic differentiation, and a rigid matrix stimulated osteogenic differentiation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Melanocyte stem cell maintenance and hair graying
Article Abstract:
The causes for hair graying, an obvious sign of human aging, are little known. However, evidence indicates that hair graying is due to incomplete melanocyte stem cell maintenance and Pax3 and Miff are key molecules that help regulate the balance between melanocyte stem cell maintenance and differentiation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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