Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family

Article Abstract:

Spo11, a member of a widely conserved protein family, is found to be the catalytic subunit of the meiotic recombination in Saccharomyces cerevisiae as initiated by double-strand breaks (DSB). Spo11 is identified as one of many proteins required for DSB formation. It is the first time that a biochemical function for any of the gene products involved in DSB formation is identified. It was also found that the S. pombe homolog rec12p is required for meiotic recombination. These results provide evidence that the mechanism of meiotic recombination initiation is highly conserved.

Analysis, Recombinant DNA, Genetic recombination, Saccharomyces, Meiosis

---

Crossover homeostasis in yeast meiosis

Article Abstract:

Homologous recombination is examined when breaks are reduced in yeast spo11 hypomorphs to understand the decision by which some breaks give crossovers while others follow a mostly noncrossover pathway(s). A previously unexpected expression of crossover control is defined whereby the crossover/noncrossover ratio can change to maintain crossovers and the theory that an obligate crossover is a genetically programmed event tied to crossover interference is supported by the results.

Science & research, Gene expression, Yeast fungi, Yeasts (Fungi), Genetic research

---

Similar abstracts:

• Abstracts: Motif module map reveals enforcement of aging by continual NF-[kappa]B activity. NF-Kb RelA opposes epidermal proliferation driven by TNFR1 and JNK
• Abstracts: Mesenchymal stem cells are recruited to striated by NFAT/IL-4-mediated cell fusion. Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression
• Abstracts: RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.