Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage

Article Abstract:

The study demonstrates that uncharacterized SET domain protein Set9 is responsible for histone lysine H4-K20 methylation in the fission yeast Schizosaccharomyces pombe. Results indicate that H4-K20 methylation does not have any apparent role in the regulation of gene expression or heterochromatin function, but functions as a 'histone mark' required for the recruitment of the checkpoint protein Crb2.

Histones, DNA damage

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EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer

Article Abstract:

Research demonstrates that EMSY protein binds BRCA2 within exon 3 region, which is deleted in cancer. It can silence the activation potential of BRCA2 exon 3 and is localized to sites of repair, following DNA damage, on chromosome 11q13.5 involved in breast and ovarian cancer. Furthermore, EMSY gene is amplified in sporadic breast cancer and advanced ovarian cancer.

United Kingdom, Canada, Netherlands, France, Analysis, Genetic aspects, Breast cancer, Ovarian cancer, Genetic regulation, Gene amplification

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A ribonucleolytic rat torpedoes RNA polymerase II

Article Abstract:

A lot of research is conducted on how mRNA chain is initiated by RNA polymerase II, however, very little information is available on the mechanism of termination at the end of the gene. Studies were conducted in this regard and findings of three papers showing similar results are discussed in brief.

RNA polymerases

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