Modulating RssB activity: IraP, a novel regulator of sigma(super s) stability in Escherichia coli

Article Abstract:

The identification and characterization of a regulator of sigma(super s), subunit of Escherichia coli RNA polymerase, stability, IraP, that stabilizes sigma(super s) both in vivo and in vitro is reported. The results reveal a novel mechanism of regulation of sigma(super s) stability through the regulation of Rssb activity and identify IraP as a member of an unknown class of regulators, the anti-adaptor proteins.

Genetic research

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DNA looping-mediated repression by histone-like protein H-NS: Specific requirement of Esigma (super 70) as a cofactor for looping

Article Abstract:

The molecular mechanism of selective repression by H-NS is investigated to identify the differences in transcription initiation by the two forms of RNA polymerase, which shows indistinguishable promoter selectivities in vitro. H-NS bound at 118 laterally extends by the cooperative recruitment of H-NS molecules to the promoter-downstream sequence joined by wrapping of the DNA around Esigma(super 70).

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A new role for histone tail modifications in transcription elongation

Article Abstract:

Positive transcription elongation factor plays a central role in early elongation. A study into its mechanisms that regulate its recruitment and activity is presented.

Genetic transcription, Transcription (Genetics), Phosphorylation

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