Molecular biology of aging

Article Abstract:

Five molecular models of aging are examined to provide an insight into the basic underlying mechanisms of aging. The models include damage by reactive oxygen species produced by metabolism, genetically programmed extension mechanisms, genome instability, cell death and systemic aging. The objective is to show that aging is amenable to molecular analysis and may be relatively simple. Results indicate limitations in the study of mammalian aging which include the paucity of reliable and easily measured biological markers for the aging phenotype.

Research

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MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks

Article Abstract:

A study was conducted to examine the transformation of the role of Sir3p, one of the three components of the yeast silent information regulatory complex, once it is released from telomeres. Results suggest that Sir3p's dissociation from telomeres is induced by DNA double-stranded breaks (DSBs). Sir3 has been observed to bind with DSBs and mediate their repair by interacting with the DNA damage checkpoint genes MRC1 and RAD9.

Physiological aspects, DNA repair, Telomeres, DNA damage, Yeast, Yeast (Food product)

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Extrachromosomal rDNA circles- A cause of aging in yeast

Article Abstract:

Studies of aging yeast mother cells reveal a progressive enlargement and fragmentation of the nucleolus. It is now shown that the nucleolar changes may be due to accumulated extrachromosomal rDNA circles (ERCs) in old cells. The yeast homolog of the Werner's syndrome gene sgs1 accumulated ERCs more quickly resulting in premature aging and shorter life span.

Observations, Extrachromosomal DNA

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